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1

Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators

Lawrence G. Hamann, Mark C. Manfredi, Chongqing Sun, Stanley R. Krystek Jr., Yanting Huang, Yingzhi Bi, David J. Augeri, Tammy Wang, Yan Zou, David. A. Betebenner, Aberra Fura, Ramakrishna Seethala, R

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 169 KB

english, 2007

2

Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin Scaffold†

Sun, Chongqing, Robl, Jeffrey A., Wang, Tammy C., Huang, Yanting, Kuhns, Joyce E., Lupisella, John A., Beehler, Blake C., Golla, Rajasree, Sleph, Paul G., Seethala, Ramakrishna

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 168 KB

english, 2006

3

A Homogeneous, Fluorescence Polarization Assay for Src-Family Tyrosine Kinases

Ramakrishna Seethala, Rolf Menzel

Journal:

Analytical Biochemistry

Année:

1997

Langue:

english

Fichier:

PDF, 221 KB

english, 1997

4

A Fluorescence Polarization Competition Immunoassay for Tyrosine Kinases

Ramakrishna Seethala, Rolf Menzel

Journal:

Analytical Biochemistry

Année:

1998

Langue:

english

Fichier:

PDF, 120 KB

english, 1998

5

Homoagmatine from Lathyrus sativus seedlings

Seethala Ramakrishna, P.Radhakantha Adiga

Journal:

Année:

1973

Langue:

english

Fichier:

PDF, 512 KB

english, 1973

6

Amine biosynthesis in Lathyrus sativus seedlings

Seethala Ramakrishna, P.Radhakantha Adiga

Journal:

Année:

1974

Langue:

english

Fichier:

PDF, 519 KB

english, 1974

7

Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators

Mark C. Manfredi, Yingzhi Bi, Alexandra A. Nirschl, James C. Sutton, Ramakrishna Seethala, Rajasree Golla, Blake C. Beehler, Paul G. Sleph, Gary J. Grover, Jacek Ostrowski, Lawrence G. Hamann

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 156 KB

english, 2007

8

A homogeneous scintillation proximity assay for acetyl coenzyme A carboxylase coupled to fatty acid synthase

Ramakrishna Seethala, Zhengping Ma, Rajasree Golla, Dong Cheng

Journal:

Analytical Biochemistry

Année:

2006

Langue:

english

Fichier:

PDF, 272 KB

english, 2006

9

A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPARα/γ activator

Ramakrishna Seethala, Rajasree Golla, Zhengping Ma, Hao Zhang, Kevin O’Malley, Jonathan Lippy, Lin Cheng, Kasim Mookhtiar, Dennis Farrelly, Litao Zhang, Narayanan Hariharan, Peter T.W. Cheng

Journal:

Analytical Biochemistry

Année:

2007

Langue:

english

Fichier:

PDF, 299 KB

english, 2007

10

A simple homogeneous scintillation proximity assay for acyl-coenzyme A:diacylglycerol acyltransferase

Ramakrishna Seethala, Tara Peterson, Jessica Dong, Ching-Hsuen Chu, Luping Chen, Rajasree Golla, Zhengping Ma, Reshma Panemangalore, R. Michael Lawrence, Dong Cheng

Journal:

Analytical Biochemistry

Année:

2008

Langue:

english

Fichier:

PDF, 275 KB

english, 2008

11

Cofactor-specific modulation of 11β-hydroxysteroid dehydrogenase 1 inhibitor potency

Bhavana Sahni-Arya, Michael J. Flynn, Laurie Bergeron, Mary Ellen K. Salyan, Donna L. Pedicord, Rajasree Golla, Zhengping Ma, Haixia Wang, Ramakrishna Seethala, Shung C. Wu, James J. Li, Akbar Nayeem,

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Année:

2007

Langue:

english

Fichier:

PDF, 403 KB

english, 2007

12

Discovery and structure–activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists

Wu Yang, Yufeng Wang, Jacques Y. Roberge, Zhengping Ma, Yalei Liu, R. Michael Lawrence, David P. Rotella, Ramakrishna Seethala, Jean H.M. Feyen, John K. Dickson Jr.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 122 KB

english, 2005

13

Discovery of tertiary aminoacids as dual PPARα/γ agonists-I

Pratik V. Devasthale, Sean Chen, Yoon Jeon, Fucheng Qu, Denis E. Ryono, Wei Wang, Hao Zhang, Lin Cheng, Dennis Farrelly, Rajasree Golla, Gary Grover, Zhengping Ma, Lisa Moore, Ramakrishna Seethala, We

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 612 KB

english, 2007

14

Tetrazole based amides as growth hormone secretagogues

James J. Li, Haixia Wang, Jun Li, Fucheng Qu, Stephen G. Swartz, Andrés S. Hernández, Scott A. Biller, Jeffrey A. Robl, Joseph A. Tino, Dorothy Slusarchyk, Ramakrishna Seethala, Paul Sleph, Mujing Yan

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 130 KB

english, 2008

15

(d)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: Synthesis and incorporation into the growth hormone secretagogues

Jun Li, Stephanie Y. Chen, Brian J. Murphy, Neil Flynn, Ramakrishna Seethala, Dorothy Slusarchyk, Mujing Yan, Paul Sleph, Hongjian Zhang, William G. Humphreys, William R. Ewing, Jeffrey A. Robl, David

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 165 KB

english, 2008

16

Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase

Tasir S. Haque, Ningning Liang, Rajasree Golla, Ramakrishna Seethala, Zhengping Ma, William R. Ewing, Christopher B. Cooper, Mary Ann Pelleymounter, Michael A. Poss, Dong Cheng

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 286 KB

english, 2009

17

Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1)

Haixia Wang, Jeffrey A. Robl, Lawrence G. Hamann, Ligaya Simpkins, Rajasree Golla, Yi-Xin Li, Ramakrishna Seethala, Tatyana Zvyaga, David A. Gordon, James J. Li

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2011

18

Diamine oxidase of Lathyrus sativus seedlings

M.Rangarajan Suresh, Seethala Ramakrishna, P.Radhakantha Adiga

Journal:

Année:

1976

Langue:

english

Fichier:

PDF, 422 KB

english, 1976

19

Regulation of arginine decarboxylase and putrescine levels in Cucumis sativus cotyledons

M.Rangarajan Suresh, Seethala Ramakrishna, P. Radhakantha Adiga

Journal:

Année:

1978

Langue:

english

Fichier:

PDF, 749 KB

english, 1978

20

Amine levels in Lathyrus sativus seedlings during development

Seethala Ramakrishna, P.Radhakantha Adiga

Journal:

Année:

1975

Langue:

english

Fichier:

PDF, 630 KB

english, 1975

21

Synthesis and structure–activity relationship of 3-arylbenzoxazines as selective estrogen receptor β agonists

Wu Yang, Yufeng Wang, Zhengping Ma, Rajasree Golla, Terry Stouch, Ramakrishna Seethala, Susan Johnson, Rong Zhou, Timur Güngör, Jean H.M Feyen, John K Dickson Jr.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 326 KB

english, 2004

22

Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues

James J. Li, Haixia Wang, Fucheng Qu, Christa Musial, Joseph A. Tino, Jeffrey A. Robl, Dorothy Slusarchyk, Rajasree Golla, Ramakrishna Seethala, Kenneth Dickinson, Leah Giupponi, Gary Grover, Paul Sle

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 115 KB

english, 2005

23

Decarboxylation of homoarginine and lysine by an enzyme from Lathyrus sativus seedlings

Seethala Ramakrishna, P.Radhakantha Adiga

Journal:

Année:

1976

Langue:

english

Fichier:

PDF, 414 KB

english, 1976

24

Discovery and Structure−Activity Relationships of Trisubstituted Pyrimidines/Pyridines as Novel Calcium-Sensing Receptor Antagonists

Ruan, Zheming, Wang, Yufeng, Van Kirk, Katy, Ma, Zhengping, Arey, Brian J., Cooper, Christopher B., Seethala, Ramakrishna, Feyen, Jean H. M., Dickson, John K., Yang, Wu

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 223 KB

english, 2009

25

Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1)

Xiang-Yang Ye, Stephanie Y. Chen, Akbar Nayeem, Rajasree Golla, Ramakrishna Seethala, Mengmeng Wang, Timothy Harper, Bogdan G. Sleczka, Yi-Xin Li, Bin He, Mark Kirby, David A. Gordon, Jeffrey A. Robl

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 2.12 MB

english, 2011

26

Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1)

Shung C. Wu, David Yoon, Janice Chin, Katy van Kirk, Ramakrishna Seethala, Rajasree Golla, Bin He, Thomas Harrity, Lori K. Kunselman, Nathan N. Morgan, Randolph P. Ponticiello, Joseph R. Taylor, Rache

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 1.19 MB

english, 2011

27

Arginine Decarboxylase from Lathyrus sativus Seedlings : Purification and Properties

Seethala RAMAKRISHNA, P. Radhakantha ADIGA

Journal:

Année:

1975

Langue:

english

Fichier:

PDF, 834 KB

english, 1975

28

Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications

Li, James J., Sutton, James C., Nirschl, Alexandra, Zou, Yan, Wang, Haixia, Sun, Chongqing, Pi, Zulan, Johnson, Rebecca, Krystek,, Stanley R., Seethala, Ramakrishna

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 278 KB

english, 2007

29

Fluorescence Polarization Competition Immunoassay for Tyrosine Kinases

Ramakrishna Seethala

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 118 KB

english, 2000

30

Phosphorylation of different sites of acetyl CoA carboxylase by ATP-citrate lyase kinase and cyclic AMP-dependent protein kinase

Seethala Ramakrishna, William B. Benjamin

Journal:

Biochemical and Biophysical Research Communications

Année:

1983

Langue:

english

Fichier:

PDF, 624 KB

english, 1983

31

Insulin stimulates phosphorylation of a heat-stable protein in rat adipose tissue

Seethala Ramakrishna, William B. Benjamin

Journal:

Biochemical and Biophysical Research Communications

Année:

1983

Langue:

english

Fichier:

PDF, 1.09 MB

english, 1983

32

Insulin stimulates the dephosphorylation of phosphothreonine from FAT-PAD ATP-citrate lyase

Seethala Ramakrishna, Dominick L. Pucci, William B. Benjamin

Journal:

Biochemical and Biophysical Research Communications

Année:

1984

Langue:

english

Fichier:

PDF, 580 KB

english, 1984

33

Phosphorylation of ATP-citrate lyase by a cyclic AMP-independent protein kinase from a rat liver

Seethala Ramakrishna, William B. Benjamin

Journal:

Année:

1981

Langue:

english

Fichier:

PDF, 394 KB

english, 1981

34

Regulation of ATP-Citrate Lyase in Rat Adipose Tissue

SEETHALA RAMAKRISHNA, WILLIAM B. BENJAMIN

Journal:

Annals of the New York Academy of Sciences

Année:

1986

Langue:

english

Fichier:

PDF, 137 KB

english, 1986

35

The relationship between levels and rates of synthesis of polyamines during mammalian cell cycle

Prasad S. Sunkara, Seethala Ramakrishna, Kenji Nishioka, Potu N. Rao

Journal:

Année:

1981

Langue:

english

Fichier:

PDF, 489 KB

english, 1981

36

Synthesis and Characterization of 3-Arylquinazolinone and 3-Arylquinazolinethione Derivatives as Selective Estrogen Receptor Beta Modulators

Güngör, Timur, Chen, Ying, Golla, Rajasree, Ma, Zhengping, Corte, James R., Northrop, John P., Bin,, Dickson, John K., Stouch, Terry, Zhou, Rong, Johnson, Susan E., Seethala, Ramakrishna, Feyen, Jean

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 256 KB

english, 2006

37

Effect of insulin on ATP-citrate lyase phosphorylation: regulation of peptide A and peptide B phosphorylations

Ramakrishna, Seethala, Murthy, Karnam Srinivasa, Benjamin, William B.

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 670 KB

english, 1989

38

Sequence of sites on ATP-citrate lyase and phosphatase inhibitor 2 phosphorylated by multifunctional protein kinase (a glycogen synthase kinase 3 like kinase)

Ramakrishna, Seethala, D'Angelo, Guy, Benjamin, William B.

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 1.50 MB

english, 1990

39

Synthesis and structure–activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)

Ye, Xiang-Yang, Yoon, David, Chen, Stephanie Y., Nayeem, Akbar, Golla, Rajasree, Seethala, Ramakrishna, Wang, Mengmeng, Harper, Timothy, Sleczka, Bogdan G., Apedo, Atsu, Li, Yi-Xin, He, Bin, Kirby, Ma

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2014

Langue:

english

Fichier:

PDF, 2.10 MB

english, 2014

40

N -Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation †△

Nirschl, Alexandra A., Zou, Yan, Krystek, Stanley R., Sutton, James C., Simpkins, Ligaya M., Lupisella, John A., Kuhns, Joyce E., Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G., Beehler, Blake

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 588 KB

english, 2009

41

Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors for the treatment of metabolic disorders

Yoon, David S., Wu, Shung C., Seethala, Ramakrishna, Golla, Rajasree, Nayeem, Akbar, Everlof, John G., Gordon, David A., Hamann, Lawrence G., Robl, Jeffrey A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2014

Langue:

english

Fichier:

PDF, 863 KB

english, 2014

42

Discovery of a Potent and Novel Motilin Agonist

Li, James J., Chao, Hann-Guang, Wang, Haixia, Tino, Joseph A., Lawrence, R. Michael, Ewing, William R., Ma, Zhengping, Yan, Mujing, Slusarchyk, Dorothy, Seethala, Ramakrishna, Sun, Huabin, Li, Danshi,

Journal:

Journal of Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 103 KB

english, 2004

43

Rapid Purification of Enzymes of Fatty Acid Biosynthesis from Rat Adipose Tissue

Ramakrishna, Seethala, Benjamin, William B.

Journal:

Preparative Biochemistry

Année:

1983

Langue:

english

Fichier:

PDF, 483 KB

english, 1983

44

Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats

Ostrowski, Jacek, Kuhns, Joyce E., Lupisella, John A., Manfredi, Mark C., Beehler, Blake C., Krystek, Stanley R., Bi, Yingzhi, Sun, Chongqing, Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G., F

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 395 KB

english, 2007

45

A Novel Calcium-Sensing Receptor Antagonist Transiently Stimulates Parathyroid Hormone Secretion in Vivo

Arey, Brian J., Seethala, Ramakrishna, Ma, Zhengping, Fura, Aberra, Morin, Jennifer, Swartz, JoAnn, Vyas, Viral, Yang, Wu, Dickson, John K., Feyen, Jean H. M.

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 384 KB

english, 2005

46

[Drugs and the Pharmaceutical Sciences] Handbook of Drug Screening Volume 20015074 || Homogeneous Assays for High-Throughput and Ultrahigh-Throughput Screening

Seethala, Ramakrishna, Fernandes, Prabhavathi

Année:

2001

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2001

47

[Drugs and the Pharmaceutical Sciences] Handbook of Drug Screening Volume 20015074 || Screening Platforms

Seethala, Ramakrishna, Fernandes, Prabhavathi

Année:

2001

Langue:

english

Fichier:

PDF, 684 KB

english, 2001

48

[Drugs and the Pharmaceutical Sciences] Handbook of Drug Screening Volume 20015074 || Receptor Screens for Small Molecule Agonist and Antagonist Discovery

Seethala, Ramakrishna, Fernandes, Prabhavathi

Année:

2001

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2001

49

BMS-192548, a Tetracyclic Binding Inhibitor of Neuropeptide Y Receptors, from Aspergillus niger WB2346. I. Taxonomy, Fermentation, Isolation and Biological Activity.

KODUKULA, KRISHNA, ARCURI, MAREDITH, CUTRONE, JINGFANG QIAN, HUGILL, ROBERT M., LOWE, SUSAN E., PIRNIK, DOLORES M., SHU, YUE-ZHONG, FERNANDES, PRABHAVATHI B., SEETHALA, RAMAKRISHNA

Journal:

The Journal of Antibiotics

Année:

1995

Langue:

english

Fichier:

PDF, 395 KB

english, 1995

50

[Drugs and the Pharmaceutical Sciences] Handbook of Drug Screening Volume 20015074 || Basic Considerations in Designing High-Throughput Screening Assays

Seethala, Ramakrishna, Fernandes, Prabhavathi

Année:

2001

Langue:

english

Fichier:

PDF, 339 KB

english, 2001